Prefrontal Cortex, Cognition, and Speech in Parkinson's Disease - NINDS Udall P20 

Our goal is to catalyze novel collaborations that will lead to an Udall Center of Excellence. We will test the overall hypothesis that decreased dopamine-dependent PFC 4 Hz activity impairs cognition and speech in PD. We will identify cellular and circuit mechanisms underlying PFC function and dysfunction in preclinical rodent models and in human PD patients. We will harness complementary and convergent cutting-edge techniques, such as cell-type-specific 2-photon imaging of the PFC in behaving animals, human intraoperative neurophysiology, brain imaging, and brain connectivity. Common research themes focus on the PFC in cognitive and speech symptoms of PD, neuronal oscillations, and neuronal circuits. Specific synergies among projects include our molecularly-defined circuits, shared analytic tools, and the temporal organization of cognitive and speech functions disrupted in PD


We have monthly journal clubs and weekly data meetings - email if you are interested. 

PRECIS-PD data meetings:

November 4th: Ergun Uc – P3 update                                                                                                                                                                    

Dec 2nd: Li-Chun Lin  – Intraoperative gene expression analysis of PD                                                                                                                                                       

Feb 3rd: Annie Rohl / Greenlee lab – Speech in PD                                                                                                                                                                             

March 3rd:  Jim Cavanagh – Cognitive control in PD                                                                                                                                                          

April 3rd: Johnson Zhang - TBD                                                                                                                                                                  

May 5th:  Kumar Narayanan – P50 application in PD                                                                                                                                                                        


PRECIS-PD journal clubs:

October 10th: Youngcho Kim

December 12th:      Matt Weber

January 9th: Jake Rysted

February 13th: Rachel Cole

April 10th: Greenlee lab 

May 8th: Johnson Zhang